Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice
نویسندگان
چکیده
منابع مشابه
Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice.
Acute pancreatitis is a painful, inflammatory disorder for which adequate treatments are lacking. An early, critical step in its development is the aberrant signaling of Ca(2+) within the pancreatic acinar cell. This Ca(2+) release is modulated by the intracellular Ca(2+) channel the ryanodine receptor (RYR). We have previously shown that RYR inhibition reduces pathological intra-acinar proteas...
متن کاملFetal microchimerism in mouse caerulein-induced pancreatitis model
Objective(s): Fetal microchimerism is the persistence of allogeneic cell population that transfer from the fetus to the mother. The aim of this study was to evaluate the presence of fetal microchimerism in the pancreas of the mouse with acute pancreatitis (AP).Materials and Methods: In this experimental study, female wild-type mice were mated with male EGFP+. AP model was obtained by injection ...
متن کاملCaerulein induced pancreatitis.
LETTERS Osteoporosis and liver disease: additional reasons for coeliac disease screening We read with great interest the recently published guidelines on the management of osteoporosis associated with chronic liver disease (Gut 2002;50(suppl I):i1–9). However, we would like to add a few words of comment. Associations between coeliac disease (CD) and primary biliary cirrhosis in particular and o...
متن کاملSecretagogue (Caerulein) induced pancreatitis in rodents
Acute pancreatitis is one of the most common diseases in gastroenterology. The incidence of acute pancreatitis per 100,000 population ranges from 10 to 46 per year. Two percent of all patients admitted to hospital are diagnosed with acute pancreatitis. Nevertheless even in the 21 century neither the etiology nor the pathophysiology of the disease are fully understood and causal treatment option...
متن کاملGlutathione monoethyl ester ameliorates caerulein-induced pancreatitis in the mouse.
Studies in animal models suggest that oxygen radicals may be important in the pathogenesis of acute pancreatitis. Because glutathione is an essential component of the defense against radical-mediated cellular injury, we investigated whether pancreatic glutathione content is influenced by inducing acute pancreatitis and whether augmenting the intracellular supply of glutathione would alter the c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Physiology-Gastrointestinal and Liver Physiology
سال: 2010
ISSN: 0193-1857,1522-1547
DOI: 10.1152/ajpgi.00498.2009